Youth and vitality for senescent cells
FLOWER POWER HIBISCUS is made of selected petals and buds of Hibiscus sabdariffa encapsulated with polymers from Acacia senegal. FLOWER POWER HIBISCUS is a stable, dry, preservative-free ingredient with high biological activity for the care of aged skin.
Hibiscus sabdariffa is a plant of the Malvaceae family native to Africa that has been cultivated for thousands of years. It was introduced to Asia and the Americas in the 17th century and currently occurs in all warm regions of the world. Its wide use is due to the multiplicity of applications: the leaves and flowers are consumed as food, and the fibers are an important textile product. In China, the seeds are a source of oil, and other parts of the plant are used for their medicinal properties.
Acacia senegal is a species of tree native to semi-desert regions of Sub-Saharan Africa that, in stressful situations such as heat, dryness, malnutrition, wounds and microbial infections, produces an exudate rich in heteropolysaccharides that protects the plant. Acacia gum is produced mainly in Sudan, Chad and Nigeria. In food industry, it is used in confectionery and in pharmaceutical, as emulsifier, coating film and others.
"Increases collagen synthesis in senescent fibroblasts."
A comprehensive review of the scientific literature reported a wide range of important biological activities of Hibiscus sabdariffa, which can be summarized in the following schemes:
"Increases cell proliferation of senescent fibroblasts."
FLOWER POWER HIBISCUS uses an exclusive Assessa active encapsulation technology through which fractions of Hibiscus sabdariffa hydrolyzed petals and buds are encapsulated with bioactive polymers from Acacia senegal, in a ingredient with high biological activity for the care of aged and tired skin.
Senescence is a set of phenomena that happen to cells as we age. Enzymes called sirtuins (SIRT) are related to aging and transcriptional, apoptosis and stress resistance.
Activation of SIRT1 suppresses the aging of several important cells, including dermal fibroblasts, responsible for the synthesis of Collagen, Elastin and Hyaluronic Acid. SIRT3 is mainly detected in mitochondria and is positively correlated with longevity.
SIRT1 EXPRESSION: Senescent fibroblasts exposed to 0.003% FLOWER POWER HIBISCUS showed a 26% increase.
SIRT3 EXPRESSION: Senescent fibroblasts exposed to 0.001% HIBISCUS showed a 2.4-fold increase; a 3.24-fold increase in the presence of 0.003% and of 3-fold in the presence of 0.01%.
Growth rate of young fibroblasts (P9) compared with aged (senescent) fibroblasts (P40) and senescent fibroblasts in contact with different concentrations of FLOWER POWER HIBISCUS.
Senescent fibroblasts (P40) treated with 0.01% HIBISCUS have more activity and replicate faster than young fibroblasts. Aged fibroblasts treated with 0.003% HIBISCUS show as much vigor as young ones.
As a consequence of senescence, fibroblasts produce less collagen, elastin, and hyaluronic acid.
All concentrations showed a significant increase in collagen synthesis by senescent fibroblasts: 30% increase in treated cells with 0.001%, 16% increase with 0.003% and 22% increase with 0.01%.